World Bulletin / News Desk
Open access worldwide to the new database, based on genome studies, is expected to help researchers accelerate development of new drugs and better match patients with therapies, NCI said in a statement on Monday.
"Most anti-cancer drugs that are used today are used based on their empirical activity," Dr. Yves Pommier, chief of the NCI's Laboratory of Molecular Pharmacology, said in an interview. "For most of them, we know there is a target, but they have not been connected with any genomics."
Most cancer treatments involve a lot of guess work because doctors have no way to determine how a particular patient is likely to respond to many commonly used drugs or chemotherapy, or which cancers will develop resistance.
To create the database, the NCI team sequenced 60 human cancer cell lines, generating an extensive list of cancer-specific variations for different parts of the body.
"Only about half of women with ovarian cancer respond to it," he said, noting that pharmaceutical companies would have little incentive to determine if an existing cancer drug should only be used in a subset of patients.
Many recently approved cancer drugs are targeted treatments, designed to block specific pathways that cancer cells use to grow and reproduce. Before the drugs are administered, patients are tested for the specific genetic mutations that would make the drug more likely to be beneficial to them.
Melanoma drug Zelboraf, sold by Roche Holding AG, is designed to work by targeting a specific genetic mutation found in about half of all melanomas. Pfizer Inc's cancer drug Xalkori, which targets a mutation in the ALK gene, works in about 4 percent of lung cancer patients.
Google will take on half of HTC's research and development staff -- about 2,000 people -- many of whom have already been working on the Silicon Valley firm's Pixel handset, as well as intellectual property (IP) licensing.
After 13 years orbiting the ringed planet, NASA crashed probe into Saturn’s surface
Cassini, an international project that cost $3.9 billion and included scientists from 27 nations, disintegrated as it dove into Saturn's atmosphere at a speed of 75,000 miles (120,700 kilometers) per hour.
Company reveals 3 new iPhones, including new flagship model with facial recognition software
The firm along with SAIC Volkswagen and FAW-Volkswagen are calling back the vehicles owing to a faulty fuel pump, the General Administration of Quality Supervision, Inspection and Quarantine said on its website.
The platforms will also have to strengthen their oversight over all published information, deleting all illegal content while also alerting authorities to the postings.
An H-IIA rocket blasted off at about 2:30 pm (0530 GMT) from the Tanegashima space centre in southern Japan, according to the Japan Aerospace Exploration Agency (JAXA).
Event offers unprecedented chance for continuous observations across country
Turkish Statistical Institute releases results of April survey on Internet usage
A source close to the matter confirmed a New York Times report on Friday that Facebook took the unusual step of creating an app called Colorful Balloons and releasing it through a local company with no hint that the social network was involved.
The iPhone maker is the latest from Silicon Valley to face a conundrum in balancing their value for human rights and free expression against a government intent on controlling online content.
Researchers use CRISPR gene editing to remove mutation that causes heart failure
Equipped with smart ammunition system, Armed Bayraktar TB2 drones hit precise targets during tests on Sunday
Johnson, kicking off a trip to Japan, visited the robotic centre at Waseda University, which works closely with Britain's University of Birmingham on robotic technologies.
Juno spacecraft will get closest look ever at planet’s massive, centuries-old storm