World Bulletin / News Desk
Open access worldwide to the new database, based on genome studies, is expected to help researchers accelerate development of new drugs and better match patients with therapies, NCI said in a statement on Monday.
"Most anti-cancer drugs that are used today are used based on their empirical activity," Dr. Yves Pommier, chief of the NCI's Laboratory of Molecular Pharmacology, said in an interview. "For most of them, we know there is a target, but they have not been connected with any genomics."
Most cancer treatments involve a lot of guess work because doctors have no way to determine how a particular patient is likely to respond to many commonly used drugs or chemotherapy, or which cancers will develop resistance.
To create the database, the NCI team sequenced 60 human cancer cell lines, generating an extensive list of cancer-specific variations for different parts of the body.
"Only about half of women with ovarian cancer respond to it," he said, noting that pharmaceutical companies would have little incentive to determine if an existing cancer drug should only be used in a subset of patients.
Many recently approved cancer drugs are targeted treatments, designed to block specific pathways that cancer cells use to grow and reproduce. Before the drugs are administered, patients are tested for the specific genetic mutations that would make the drug more likely to be beneficial to them.
Melanoma drug Zelboraf, sold by Roche Holding AG, is designed to work by targeting a specific genetic mutation found in about half of all melanomas. Pfizer Inc's cancer drug Xalkori, which targets a mutation in the ALK gene, works in about 4 percent of lung cancer patients.
Tech giant Apple reported Tuesday a 6 percent increase to $37.4 billion in quarterly revenue after selling 35.2 million iPhones.
The total number of online access devices projected to rise to 50 billion in 2020 and 100 billion in 2030.
Tasmania is currently the only Australian state that bans genetically modified food crops and animal feed.
U.S. Magistrate Judge Gabriel Gorenstein said Friday he had authorized a warrant to be served on Google Inc for the emails of an unnamed individual who is the target of a money laundering investigation.
The freighter was loaded with more than 3,660 pounds (1,660 kg) of food, science equipment and supplies for the space station, a $100 billion research laboratory
The remains include two Tyrannosaurus bataar skeletons, a fossilized egg and a well-preserved 'nest' of several Oviraptor skeletons.
The MindRDR software monitors high levels of concentration, allowing users to take photographs and post it online without even having to move.
Angara rockets are a key to President Vladimir Putin's effort to reform a once-pioneering space industry hobbled after years of budget cuts and a brain drain in the 1990s.
It is hoped that by 2040 drones will be able to use 3D printers to print out mini-drones and repair themselves.
Russian Presidnt Vladimir Putin denied he was restricting web freedoms, saying his main concern was protecting children from indecent content.
Producing stem cells has become fast, easy, and inexpensive.
It's believed that a collision of two asteroids out in space caused a shower of meteors to rain down on Earth during the Ordovician Period some 470 million years ago.
Scientists discovered that wild chimps communicate 19 specific messages to one another with a “lexicon” of 66 gestures.
The ‘Smartcane’ is a new device that uses ultrasound to guide the visually impaired through the busy streets of India by building upon the widely used white cane.
Earthquake activity in Oklahoma has skyrocketed in recent years, and the U.S. Geological Survey recently warned that the state faces increasing risk of more potentially damaging earth-shaking activity
Scientists have developed a new technique to regrow human corneas.