World Bulletin / News Desk
Open access worldwide to the new database, based on genome studies, is expected to help researchers accelerate development of new drugs and better match patients with therapies, NCI said in a statement on Monday.
"Most anti-cancer drugs that are used today are used based on their empirical activity," Dr. Yves Pommier, chief of the NCI's Laboratory of Molecular Pharmacology, said in an interview. "For most of them, we know there is a target, but they have not been connected with any genomics."
Most cancer treatments involve a lot of guess work because doctors have no way to determine how a particular patient is likely to respond to many commonly used drugs or chemotherapy, or which cancers will develop resistance.
To create the database, the NCI team sequenced 60 human cancer cell lines, generating an extensive list of cancer-specific variations for different parts of the body.
"Only about half of women with ovarian cancer respond to it," he said, noting that pharmaceutical companies would have little incentive to determine if an existing cancer drug should only be used in a subset of patients.
Many recently approved cancer drugs are targeted treatments, designed to block specific pathways that cancer cells use to grow and reproduce. Before the drugs are administered, patients are tested for the specific genetic mutations that would make the drug more likely to be beneficial to them.
Melanoma drug Zelboraf, sold by Roche Holding AG, is designed to work by targeting a specific genetic mutation found in about half of all melanomas. Pfizer Inc's cancer drug Xalkori, which targets a mutation in the ALK gene, works in about 4 percent of lung cancer patients.
Iceland will be ready to start using magma to generate electricity in 2015.
Lockheed Martin and Electro Optic Systems (EOS) will set up a new tracking station will be based in Western Australia.
Scientists at the Harbin Institute of Technology have discovered a way to allow submerged vessels to travel fast than the speed of sound under water at around 3,600 miles per hour.
Iceland produces almost all the energy it consumes through renewable energy sources, according to Iceland's Energy Authority report.
Information belonging to tens of millions of Sony customers was put at risk by cyber attack on gaming network.
The popular website UFO Blogger compared the find to previous images of a “fossilized, reptilian spine” and a “human finger.”
The two-day fair showcases products like control and surveillance equipment; mine and bomb detectors and aviation security.
Scientists hope to use information about how the organisms fare in the highly radioactive and extreme temperatures of space to devise life-detection techniques for future robotic Mars missions.
The congress will bring together more than 200 of the world's global digital and tech leaders.
Asteroid 1950 DA could hit the Earth on 16 March, 2880.
Anonymous had its account suspended after leaking the name of a police officer accused of shooting dead a black teenager.
Mirzakhani was recognised for her work in understanding the symmetry of curved surfaces, according to the Stanford site.
The cargo includes a European-built electromagnetic levitator, which will be used to suspend and heat metal samples in weightlessness with the goal of improving industrial casting processes
The site, called BrownList (http://www.brownlist.com/), carries the motto "It's payback time."
Last year, China launched a campaign to clamp down on online rumour mongering and 'clean up' the internet.
In May 2014, a court in the US found that both companies had infringed on one another's patents, putting Samsung on the hook for $119.6 million, and Apple down for a mere $158,400.