World Bulletin / News Desk
Open access worldwide to the new database, based on genome studies, is expected to help researchers accelerate development of new drugs and better match patients with therapies, NCI said in a statement on Monday.
"Most anti-cancer drugs that are used today are used based on their empirical activity," Dr. Yves Pommier, chief of the NCI's Laboratory of Molecular Pharmacology, said in an interview. "For most of them, we know there is a target, but they have not been connected with any genomics."
Most cancer treatments involve a lot of guess work because doctors have no way to determine how a particular patient is likely to respond to many commonly used drugs or chemotherapy, or which cancers will develop resistance.
To create the database, the NCI team sequenced 60 human cancer cell lines, generating an extensive list of cancer-specific variations for different parts of the body.
"Only about half of women with ovarian cancer respond to it," he said, noting that pharmaceutical companies would have little incentive to determine if an existing cancer drug should only be used in a subset of patients.
Many recently approved cancer drugs are targeted treatments, designed to block specific pathways that cancer cells use to grow and reproduce. Before the drugs are administered, patients are tested for the specific genetic mutations that would make the drug more likely to be beneficial to them.
Melanoma drug Zelboraf, sold by Roche Holding AG, is designed to work by targeting a specific genetic mutation found in about half of all melanomas. Pfizer Inc's cancer drug Xalkori, which targets a mutation in the ALK gene, works in about 4 percent of lung cancer patients.
According to documents released in March by Wikileaks, US intelligence can hack smartphones, computers and smart, web-connected TVs, to pilot them and eavesdrop.
"IOT home appliances, things that can be used in our everyday lives, our cars, lights, refrigerators, everything like this that is connected can be used and weaponised to spy on us or harm us."
The deal enables GE's "Geneva" to communicate with the Google Assistant, so users can say: "Ok Google, ask Geneva Home to set the oven timer for 10 minutes."
The malware uses a hacking tool known as EternalBlue, which was published last month by an anonymous hacking group called Shadow Brokers, saying it had been obtained from the US National Security Agency.
Firms say they will also focus on developing 5G technology, following recent deal
European policing and security agencies said the fallout from a ransomware attack that has already crippled more than 200,000 computers around the world could deepen as people return for another work week.
The head of the pan-European Union policing agency said that few had given in to the demands for payment to unblock files so far, but warned that the situation was escalating.
Microsoft's aim on Wednesday was on businesses and software developers, whether they been students building a fun app or professional technology teams.
The firm's market capitalization climbed to $815.08 billion on Monday -- a first for any company in history
WeChat, which had 889 million global users by the end of 2016, was not properly registered with Russian regulators, Tencent said.
The survey released Thursday by Strategy Analytics showed Apple grabbed a 15.9 percent share of the wearables market in the first quarter.
According to the Washington Post reports,the investigation into Uber's secret software is in its early stages
China is under pressure to write its own encyclopaedia so it can guide public thought, according to a statement by the project's executive editor Yang Muzhi published last month on the website of the Chinese Academy of Sciences.
nuTonomy will install its software, along with sensors and computing platforms, into customised Peugeot 3008 vehicles, with the vehicles expected to hit the streets in September.
The payload for the National Reconnaissance Office, which makes and operates spy satellites for the United States, soared into the sky atop a Falcon 9 rocket at 7:15 am (1115 GMT).