World Bulletin / News Desk
Open access worldwide to the new database, based on genome studies, is expected to help researchers accelerate development of new drugs and better match patients with therapies, NCI said in a statement on Monday.
"Most anti-cancer drugs that are used today are used based on their empirical activity," Dr. Yves Pommier, chief of the NCI's Laboratory of Molecular Pharmacology, said in an interview. "For most of them, we know there is a target, but they have not been connected with any genomics."
Most cancer treatments involve a lot of guess work because doctors have no way to determine how a particular patient is likely to respond to many commonly used drugs or chemotherapy, or which cancers will develop resistance.
To create the database, the NCI team sequenced 60 human cancer cell lines, generating an extensive list of cancer-specific variations for different parts of the body.
"Only about half of women with ovarian cancer respond to it," he said, noting that pharmaceutical companies would have little incentive to determine if an existing cancer drug should only be used in a subset of patients.
Many recently approved cancer drugs are targeted treatments, designed to block specific pathways that cancer cells use to grow and reproduce. Before the drugs are administered, patients are tested for the specific genetic mutations that would make the drug more likely to be beneficial to them.
Melanoma drug Zelboraf, sold by Roche Holding AG, is designed to work by targeting a specific genetic mutation found in about half of all melanomas. Pfizer Inc's cancer drug Xalkori, which targets a mutation in the ALK gene, works in about 4 percent of lung cancer patients.
European politicians have grown increasingly concerned about Google's and other American companies' command of the Internet industry, and have sought ways to curb their power
NSA chief Rogers said digital attackers have been able to penetrate such systems and perform "reconnaissance" missions to determine how the networks are put together.
World's largest atomic laboratory finds two subatomic particles; discovery alters shape of physics.
When bank employees were primed to think less about their profession and more about normal life, they were less inclined to dishonesty.
Comets date back to the formation of our solar system and have preserved ancient organic molecules like a time capsule.
The State Department's network was infiltrated last month, but the department did not disconnect the affected systems until over the weekend, according to federal technology information website
Before dying, Philae defied the odds and radioed its science results back to Earth for analysis.
New funds from the Department of Energy will go toward building supercomputers for nuclear weapons and other research.
The presidential library statement said that 50,000 books and archive documents from 27 libraries around Russia had already been handed over for the process of establishing the "alternative Wikipedia".
Hackers could potentially steal login credentials, access sensitive data stored on iOS devices and remotely monitor activity on those devices, the government said.
First spacecraft in history to land on comet's surface posts photos on its twitter account.
The Israeli newspaper Yedioth Ahronoth quoted one of the group members as saying that his group had already accessed and blocked the website of the Palestinian Interior Ministry on Tuesday
A spacecraft from Earth lands on the surface of a comet for the first time in history
Its operations will include news wires, a radio station, an Internet site, applications for mobile phones and social media as well as press centres in some countries.
U.S. President Barack Obama says the agency should reclassify broadband to regulate it more like a public utility.
The Barak 8 system is designed to shoot down incoming aircraft or missiles from land or sea platforms.