World Bulletin / News Desk
Open access worldwide to the new database, based on genome studies, is expected to help researchers accelerate development of new drugs and better match patients with therapies, NCI said in a statement on Monday.
"Most anti-cancer drugs that are used today are used based on their empirical activity," Dr. Yves Pommier, chief of the NCI's Laboratory of Molecular Pharmacology, said in an interview. "For most of them, we know there is a target, but they have not been connected with any genomics."
Most cancer treatments involve a lot of guess work because doctors have no way to determine how a particular patient is likely to respond to many commonly used drugs or chemotherapy, or which cancers will develop resistance.
To create the database, the NCI team sequenced 60 human cancer cell lines, generating an extensive list of cancer-specific variations for different parts of the body.
"Only about half of women with ovarian cancer respond to it," he said, noting that pharmaceutical companies would have little incentive to determine if an existing cancer drug should only be used in a subset of patients.
Many recently approved cancer drugs are targeted treatments, designed to block specific pathways that cancer cells use to grow and reproduce. Before the drugs are administered, patients are tested for the specific genetic mutations that would make the drug more likely to be beneficial to them.
Melanoma drug Zelboraf, sold by Roche Holding AG, is designed to work by targeting a specific genetic mutation found in about half of all melanomas. Pfizer Inc's cancer drug Xalkori, which targets a mutation in the ALK gene, works in about 4 percent of lung cancer patients.
Fears brewing in financial hub that further moves by government to censor content could scare foreign SME away.
Samsung's share slipped to 46 percent after hovering around 60 percent for five months.
He cited Facebook, WhatsApp and Snapchat as examples of online communication channels which were difficult for intelligence agencies to access.
Obama's proposal includes measures to allow for the prosecution of the sale of botnets, computer networks linked to cybercrime, and would give courts the power to shut down those responsible for distributed denial of service attacks.
Hackers posted threats and contact information of US military personnel.
Researchers said the antibiotic, which has yet to be trialled in humans, could one day be used to treat drug-resistant infections caused by the superbug MSRA, as well as tuberculosis
For the first time, frogs have been seen giving birth to tadpoles.
A hacker activist group known as Lizard Squad said it was responsible for the PSN outage as well as delays on Microsoft's Corp's Xbox network; Microsoft quickly fixed the problem.
Chancellor Angela Merkel's government wants to bring 1 million battery-powered vehicles onto the roads of Europe's largest economy by the end of the decade.
North Korea experienced Internet problems last weekend and a complete outage of nearly nine hours before links were largely restored on Tuesday.
#ICantBreathe and #IAmMikeBrown are the two top trending social media hashtags of the year.
The vehicle is the first one that marries the automobile functionality and software engineering into one working car. It will be tested in 2015.
Spanish news publishers want government to negotiate with Google.
The Russian space station Mir, launched by the Soviet Union in 1986, operated until 2001 and President Vladimir Putin is now seeking to reform Russia's once-pioneering space industry
Google's action caps a decade of acrimony with news publishers who blame the search giant for revenue and readership declines
Top climate envoy gives broad support for global deal but says country's "special circumstances" must be factored.