World Bulletin / News Desk
Open access worldwide to the new database, based on genome studies, is expected to help researchers accelerate development of new drugs and better match patients with therapies, NCI said in a statement on Monday.
"Most anti-cancer drugs that are used today are used based on their empirical activity," Dr. Yves Pommier, chief of the NCI's Laboratory of Molecular Pharmacology, said in an interview. "For most of them, we know there is a target, but they have not been connected with any genomics."
Most cancer treatments involve a lot of guess work because doctors have no way to determine how a particular patient is likely to respond to many commonly used drugs or chemotherapy, or which cancers will develop resistance.
To create the database, the NCI team sequenced 60 human cancer cell lines, generating an extensive list of cancer-specific variations for different parts of the body.
"Only about half of women with ovarian cancer respond to it," he said, noting that pharmaceutical companies would have little incentive to determine if an existing cancer drug should only be used in a subset of patients.
Many recently approved cancer drugs are targeted treatments, designed to block specific pathways that cancer cells use to grow and reproduce. Before the drugs are administered, patients are tested for the specific genetic mutations that would make the drug more likely to be beneficial to them.
Melanoma drug Zelboraf, sold by Roche Holding AG, is designed to work by targeting a specific genetic mutation found in about half of all melanomas. Pfizer Inc's cancer drug Xalkori, which targets a mutation in the ALK gene, works in about 4 percent of lung cancer patients.
Research finds 4.5-billion-year-old moon formed few million years after Earth
In Europe, green cars benefit increasingly from subsidies, tax breaks and other perks, while combustion engines face mounting penalties including driving and parking restrictions.
Automation has transformed the productivity of manufacturing since industrial robots first started painting, cutting, welding and assembling in the 1960s.
The Marines's version of the plane, known as the F-35B, is capable of conducting short takeoffs and vertical landings.
An unmanned SpaceX Falcon 9 rocket exploded September 1 in Cape Canaveral, destroying a satellite that Facebook planned to use to beam high-speed internet to Africa.
English, Chinese versions removed following government request
Scientists at the University of California, Berkeley, and the University of York, England, corroborated the results of the National Oceanic and Atmospheric Administration's (NOAA) research paper in 2015.
The South Korean automaker wants to stand out by being ordinary: making a self-driving car for the average consumer.
New $100 billion fund initiated by Japanese bank finds supporters in Foxconn, Saudi Arabia and Oracle
Turmaks establishes a facility to produce silicopolymer recycling technology in the Netherlands
The rocket is set to blast off from the southern spaceport of Sriharikota in February carrying three Indian satellites and 100 foreign ones including from the US, France and Germany, the Press Trust of India said.
A new design takes on Tesla surpassing key benchmarks
The factory will make large-screen liquid crystal displays (LCD), the firm said at an event in the Chinese city on Friday. It will be operational by 2019.
"The first A380 with a Rolls Royce engine has been delivered to Emirates Airline," a spokesman for the aerospace giant said.
Finland, once a world leader in mobile telephony with Nokia, is in a class of its own when it comes to internet usage on smartphones and tablets, thanks to cheap subscription plans.
'Milestone' technology bank to help least-developed countries to be housed in Kocaeli, 70 km from Istanbul, says TUBITAK