World Bulletin / News Desk
Open access worldwide to the new database, based on genome studies, is expected to help researchers accelerate development of new drugs and better match patients with therapies, NCI said in a statement on Monday.
"Most anti-cancer drugs that are used today are used based on their empirical activity," Dr. Yves Pommier, chief of the NCI's Laboratory of Molecular Pharmacology, said in an interview. "For most of them, we know there is a target, but they have not been connected with any genomics."
Most cancer treatments involve a lot of guess work because doctors have no way to determine how a particular patient is likely to respond to many commonly used drugs or chemotherapy, or which cancers will develop resistance.
To create the database, the NCI team sequenced 60 human cancer cell lines, generating an extensive list of cancer-specific variations for different parts of the body.
"Only about half of women with ovarian cancer respond to it," he said, noting that pharmaceutical companies would have little incentive to determine if an existing cancer drug should only be used in a subset of patients.
Many recently approved cancer drugs are targeted treatments, designed to block specific pathways that cancer cells use to grow and reproduce. Before the drugs are administered, patients are tested for the specific genetic mutations that would make the drug more likely to be beneficial to them.
Melanoma drug Zelboraf, sold by Roche Holding AG, is designed to work by targeting a specific genetic mutation found in about half of all melanomas. Pfizer Inc's cancer drug Xalkori, which targets a mutation in the ALK gene, works in about 4 percent of lung cancer patients.
Police Commissioner Bill Bratton said on Wednesday he would continue and expand the NYPD Twitter campaign a day after it backfired, triggering an outpouring of negative images
Deals on connections that happen before they reach the user, known as interconnection agreements, are outside of their scope.
Rousseff spoke at a global conference that she convened on how to govern a safer, less U.S.-centered Internet after revelations that she and other world leaders had been spied upon by the NSA
The arrests came as Cambodia prepares its first Cyber Crime law, a draft of which has been criticised as contains measures meant to silence criticism of government.
City-killer asteroids are forecast to strike about once every 100 years, but the prediction is not based on hard evidence.
The two-day Net Mundial conference in Sao Paulo will discuss cyber security and how to safeguard privacy and freedom of expression on the Internet, as well as the shape of a future international body
Though the overall number of spying incidents studied tripled to 511 from total in the 2013 Verizon report, most of that increase is due to the addition of new data sources
There were no reports of damage but the ball of fire raised eyebrows after a meteorite crashed to Earth near the Russian city of Chelyabinsk
NASA officials had planned to crash the spacecraft into the moon, after it transmitted its final batch of data.
The discovery is the closest scientists have come so far to finding a true Earth twin
An ambitious project in Turkey's south could see a pioneering clean energy project.
Depending on local weather conditions, the eclipse was visible across a swath of the United States
Google and Facebook have been competing in innovative ways to increase internet access globally and tap into previously untouched markets.
A 14-year-old Dutch girl who sent a terror threat to American Airlines as a Twitter “joke” has been arrested by police in Rotterdam
The legal action is the first to emerge from a humiliating episode for Microsoft, which the software company has never fully explained and has accounted for only as a "technical error."