World Bulletin / News Desk
Open access worldwide to the new database, based on genome studies, is expected to help researchers accelerate development of new drugs and better match patients with therapies, NCI said in a statement on Monday.
"Most anti-cancer drugs that are used today are used based on their empirical activity," Dr. Yves Pommier, chief of the NCI's Laboratory of Molecular Pharmacology, said in an interview. "For most of them, we know there is a target, but they have not been connected with any genomics."
Most cancer treatments involve a lot of guess work because doctors have no way to determine how a particular patient is likely to respond to many commonly used drugs or chemotherapy, or which cancers will develop resistance.
To create the database, the NCI team sequenced 60 human cancer cell lines, generating an extensive list of cancer-specific variations for different parts of the body.
"Only about half of women with ovarian cancer respond to it," he said, noting that pharmaceutical companies would have little incentive to determine if an existing cancer drug should only be used in a subset of patients.
Many recently approved cancer drugs are targeted treatments, designed to block specific pathways that cancer cells use to grow and reproduce. Before the drugs are administered, patients are tested for the specific genetic mutations that would make the drug more likely to be beneficial to them.
Melanoma drug Zelboraf, sold by Roche Holding AG, is designed to work by targeting a specific genetic mutation found in about half of all melanomas. Pfizer Inc's cancer drug Xalkori, which targets a mutation in the ALK gene, works in about 4 percent of lung cancer patients.
Depending on local weather conditions, the eclipse was visible across a swath of the United States
Google and Facebook have been competing in innovative ways to increase internet access globally and tap into previously untouched markets.
A 14-year-old Dutch girl who sent a terror threat to American Airlines as a Twitter “joke” has been arrested by police in Rotterdam
The legal action is the first to emerge from a humiliating episode for Microsoft, which the software company has never fully explained and has accounted for only as a "technical error."
The widespread bug surfaced late on Monday, when it was disclosed that a pernicious flaw in a widely used Web encryption program known as OpenSSL opened hundreds of thousands of websites to data theft.
For some, increased connectivity has allowed them to see social network and sharing websites like Youtube and Facebook for the first time.
The suspects exploited the fact that some users had the same pin number or password for both credit cards and the loyalty card to create fake cards and charge items earlier this year
The radar is part of a safety system that ensures a failed rocket will not threatened populated areas.
The World's latest solar energy technologies with innovative products produced in Turkey will be showcased at the fair.
Kaspersky Lab uncovered evidence that a few hacking groups believed to be involved in state-sponsored cyber espionage were running such scans shortly after news of the bug first surfaced
Facebook did not specify how many ads will now appear in the right-hand column, though a sample image on the blog showed a single ad in the right-hand column
StoreDot's device charged a dead Samsung S4 smartphone battery in 26 seconds during a demonstration of the product.
Weapons like the electromagnetic rail gun could help U.S. forces retain their edge and give them an asymmetric advantage over rivals, making it too expensive to use missiles to attack U.S. warships because of the cheap way to defeat them.
Google and Facebook generally topped lists of Americans' concerns about the ability to track physical locations and monitor spending habits and personal communications
Anonymous, a loosely associated international network of hackers, said earlier that it would wage an anti-Israel operation, dubbed #OpIsrael, on Monday.