World Bulletin / News Desk
Open access worldwide to the new database, based on genome studies, is expected to help researchers accelerate development of new drugs and better match patients with therapies, NCI said in a statement on Monday.
"Most anti-cancer drugs that are used today are used based on their empirical activity," Dr. Yves Pommier, chief of the NCI's Laboratory of Molecular Pharmacology, said in an interview. "For most of them, we know there is a target, but they have not been connected with any genomics."
Most cancer treatments involve a lot of guess work because doctors have no way to determine how a particular patient is likely to respond to many commonly used drugs or chemotherapy, or which cancers will develop resistance.
To create the database, the NCI team sequenced 60 human cancer cell lines, generating an extensive list of cancer-specific variations for different parts of the body.
"Only about half of women with ovarian cancer respond to it," he said, noting that pharmaceutical companies would have little incentive to determine if an existing cancer drug should only be used in a subset of patients.
Many recently approved cancer drugs are targeted treatments, designed to block specific pathways that cancer cells use to grow and reproduce. Before the drugs are administered, patients are tested for the specific genetic mutations that would make the drug more likely to be beneficial to them.
Melanoma drug Zelboraf, sold by Roche Holding AG, is designed to work by targeting a specific genetic mutation found in about half of all melanomas. Pfizer Inc's cancer drug Xalkori, which targets a mutation in the ALK gene, works in about 4 percent of lung cancer patients.
Apple is striving to improve the environmental impact of its supply chain, which is responsible for more than 70 percent of its total carbon footprint, the official Xinhua news agency reported.
Social network to be integrated into Windows software in coming months, CEO says
New supermarket features no human cashiers, scheduled to open to public in early 2017
The organization cited missing letters in some words or mistakes in verses and punctuation in free Quran apps
The intervention in a Chinese company’s bid to buy German chip maker, Aixtron, comes after Chinese companies have spent billions to acquire technology in Europe and the United States.
Malware designed for cellphones are designed to steal email addresses and authentication data stored on the devices to access sensitive data from Gmail, Google Photos, Google Docs and other services, Check Point said.
Japan plans to build the world's fastest-known supercomputer as part of a government policy to get back Japan's mojo in the world of technology
The once-mighty Finnish company sold its device business to Microsoft in 2014, where phones were sold under the Lumia brand. But as Microsoft effectively exits the smartphone business, Nokia is set to return.
South Korea denied a request by Google to export digital-map date
Day after releasing new anti-harassment policies, company promotes ad for white supremacists
On trip to US, senior executives in tech industry tell investors of opportunities offered
Facebook today announced that it has purchased CrowdTangle, a 4-year-old tool that publishers use to track how content spreads around the ...
Moscow City Court has upheld a ruling to block the LinkedIn professional network website.
Neither Tesla nor Grohmann have offered details of how much money is to change hands with the Tesla purchase of Grohmann
The presidential election is being debated extensively in the world media. One of the most important topics of discussion is the effect of Google on the US election. Donald Trump has accused Google of manipulating the remaining weeks and hours are now left behind. Trump accused has Google of hiding negative search results about Clinton and showing Clinton ahead in the polls.