World Bulletin / News Desk
Open access worldwide to the new database, based on genome studies, is expected to help researchers accelerate development of new drugs and better match patients with therapies, NCI said in a statement on Monday.
"Most anti-cancer drugs that are used today are used based on their empirical activity," Dr. Yves Pommier, chief of the NCI's Laboratory of Molecular Pharmacology, said in an interview. "For most of them, we know there is a target, but they have not been connected with any genomics."
Most cancer treatments involve a lot of guess work because doctors have no way to determine how a particular patient is likely to respond to many commonly used drugs or chemotherapy, or which cancers will develop resistance.
To create the database, the NCI team sequenced 60 human cancer cell lines, generating an extensive list of cancer-specific variations for different parts of the body.
"Only about half of women with ovarian cancer respond to it," he said, noting that pharmaceutical companies would have little incentive to determine if an existing cancer drug should only be used in a subset of patients.
Many recently approved cancer drugs are targeted treatments, designed to block specific pathways that cancer cells use to grow and reproduce. Before the drugs are administered, patients are tested for the specific genetic mutations that would make the drug more likely to be beneficial to them.
Melanoma drug Zelboraf, sold by Roche Holding AG, is designed to work by targeting a specific genetic mutation found in about half of all melanomas. Pfizer Inc's cancer drug Xalkori, which targets a mutation in the ALK gene, works in about 4 percent of lung cancer patients.
Biologists have created chicken embryos with dinosaur-like faces by tinkering with the molecules that build the birds' beaks.
Product available for pre-order in nine countries but devices won’t ship for weeks.
Nobel Prize-winning scientists' discovery can be manufactured cheaper thanks to Nanografi process.
Most industry experts expect the first product of 5G technology in the run-up to the Tokyo Olympics in 2020.
The slowdown in the rate of rising temperatures, from faster gains in the 1980s and 1990s, has puzzled scientists because heat-trapping greenhouse gas emissions
The discovery challenges currently held theories that black holes and their host galaxies grew in relative lockstep over the eons.
Australian researchers are developing the new way to have a final product for Boeing Co, Airbus Group NV, very quickly than now. 3D printing can cut production times for components from three months to just six days.
Bogachev is charged in the United States with running a computer attack network called GameOver Zeus that allegedly stole more than $100 million from online bank accounts.
The account started sharing videos and photos of the militant group a few days ago
U.S., UK spies hacked SIM card maker Gemalto's system, Intercept says, giving spies ability to monitor calls on billions of phones
The next time an earthquake hits the Pacific Northwest, a handful of computers in offices across the region will have access to a software that will send out an alarm, alerting people before the earthquake strikes.
Researchers in Britain have discovered that limpet teeth exhibit a strength that is potentially higher than spider silk.
Epigenetic differences are one reason identical twins, who have identical DNA, do not always develop the same genetic diseases, including cancer.
Kaspersky said it found personal computers in 30 countries infected with one or more of the spying programs, with the most infections seen in Iran, followed by Russia, Pakistan, Afghanistan, China, Mali, Syria, Yemen and Algeria.
The makers of mobile travel app "Bey2ollak" have warn on bomb scares and resulting hold-ups in Cairo and Alexandria using the hashtag #WhereIsTheBomb.