The world's first vaccine against dengue, developed by French drugmaker Sanofi, has shown the ability to protect against disease caused by three of four dengue virus strains in a keenly awaited clinical trial in Thailand.
Sanofi said on Wednesday the proof of efficacy was "a key milestone" in the 70-year quest to develop a viable dengue shot, adding the results also confirmed the safety profile of the vaccine candidate.
The mosquito-borne disease - also known as "breakbone fever" - is a threat to nearly 3 billion people and is caused by four different types of virus, none of which confers immunity from the others.
Sanofi's vaccine generated an antibody response for all four dengue virus types, but evidence of protection was only demonstrated against three of the four circulating in Thailand. Sanofi said researchers were carrying out analyses to understand the lack of protection for the fourth serotype.
The company's vaccine unit, Sanofi Pasteur, has already invested 350 million euros ($423 million) in a new French factory to make the three-dose vaccine and believes its product could generate 1 billion euros in yearly sales.
But uptake of the vaccine will depend on precisely how well doctors believe it can protect populations at risk in fast-expanding tropical cities from Rio to Manila, as well as travelers.
Sanofi gave no details on the level of protection in a brief statement. The full data are now being reviewed by scientific experts and public health officials, with detailed results to be published later this year.
Sanofi previously said it planned to present the findings at the annual meeting of the American Society of Tropical Medicine and Hygiene in Atlanta in November.
Large-scale late-stage Phase III clinical studies with 31,000 participants are under way with Sanofi's vaccine in 10 countries in Asia and Latin America.
At present people have no option but to take lifelong, daily doses of anti-retroviral therapy (ART) which keeps the HIV virus under control, but does not kill it.
One in every 45 Yemenis will have contracted the disease by December as "a direct consequence of a conflict that has devastated civilian infrastructure and brought the whole health system to its knees," the ICRC said in a statement.
It came after state TV said the toys could make people susceptible to the messages of the political opposition.
Ultimately, the final joint statement after the summit in Hamburg underlined that the 2015 Paris deal is "irreversible", while "taking note" of Washington's decision to quit the agreement.
Health official says 18-month old boy paralyzed by polio virus in southwestern Balochistan province
Campaign aims to cover over 10M children under age of 5; 75,000 workers to participate in nationwide campaign
Four people die in most recent wave of infection; 580 more later test negative
Rai is one of hundreds of thousands of small traders fearful of the goods and services tax (GST) launched Saturday that aims to create a single market in place of a labyrinthine system of more than a dozen national and state levies.
Doctors went on 100-day strike earlier in the year, demanding 300 pct pay raise under 2013 collective bargaining deal
More than 200 scientists urge further restrictions on commonly used chemicals
Over 166,976 suspected cases of cholera have been registered in Yemen
Around 16,000 cases of watery diarrhea have been reported in Sudan since August 2016, says Abu Garda
Named "pseudouridimycin," or PUM, the new antibiotic is produced by a microbe found in the soil.
Study finds obesity rates doubled in more than 70 countries since 1980
Unhealthy foods include ice cream, cookies, pies, some cheeses, soda
More than 86,400 suspected cases of cholera recorded in war-torn Yemen