World Bulletin / News Desk
Scientists have found two distinct genetic "signatures" for prostate cancer that may help doctors predict which patients have aggressive tumours, and designed experimental blood tests to read those genetic signs like barcodes.
The teams, whose work was published on Tuesday in the Lancet Oncology journal, believe tests developed from the signatures could eventually be used to tell which patients need immediate treatment.
"Prostate cancer is a very diverse disease - some people live with it for years without symptoms but for others it can be aggressive and life-threatening," said Johann de Bono, who led a study at Britain's Institute of Cancer Research. "So it's vital we develop reliable tests to tell the different types apart."
Researchers in Britain and the United States found that by reading the patterns of genes switched on and off in blood cells, they could accurately detect which advanced prostate cancer patients had the worst survival rates.
Prostate cancer is the second most common cancer in men after lung cancer. There were 899,000 new cases diagnosed worldwide in 2008, the last year for which there is full global data, according to the World Health Organisation's International Agency for Research on Cancer.
While many cases can progress quickly, spreading to other organs and becoming deadly, experts say as many as half of prostate cancers are likely to remain confined to the prostate and are unlikely to become life-threatening.
The problem has always been knowing accurately, and at an early stage, which tumours are most likely to kill.
Although tests for aggressive forms of prostate cancer already exist, experts say they are only moderately accurate.
De Bono said scientists can learn more about prostate cancers by the signs they leave in blood. This allowed his team to develop a test potentially more accurate than those available now and easier for patients than taking a biopsy, he said.
"Our test reads the pattern of genetic activity like a barcode, picking up signs that a patient is likely to have a more aggressive cancer. Doctors should then be able to adjust the treatment they give accordingly," he said in a statement.
For his study, De Bono's team scanned all the genes in blood samples from 100 patients in London and Glasgow with prostate cancer. They included some already diagnosed with advanced cancer and some thought to have low-risk, early-stage cancer.
Using statistical modelling, the team divided the patients into four groups according to patterns of gene activity and, after almost two-and-a-half years, they found patients in one group had died significantly earlier than those in the others.
They pinpointed nine key active genes shared by all patients in that group, and when they tested another 70 Americans with prostate cancer, they again found these genes identified patients who survived for a shorter time - around 9 months compared to over 21 months for those without the gene pattern.
The second study by researchers in the United States identified a set of six genes linked to a more aggressive form of prostate cancer in a group of 62 patients at the Dana-Farber Cancer Institute in Boston. The signature divided patients into two groups: one with an average survival time of 7.8 months and the other with an average survival of at least 34.9 months.
The British team said their signature included several genes involved in the immune system - suggesting the immune system is suppressed in patients whose cancers spread around the body.
Commenting on the work in The Lancet Oncology, Karina Dalsgaard Sorensen at Denmark's Aarhus University Hospital, who was not involved in either study, said the findings were welcome and significant.
"These results suggest that a few selected genes in blood samples from patients...can significantly improve the prediction of outcomes," she said.
Number just 1 million shy of those who would have been without coverage under previous Republican draft
The human genome has some 25,000 genes composed of more than three billion pairing of building-block molecules.
On a pro-forma 2016 basis, the merged group would have combined sales of approximately $13.2 billion (11.8 billion euros) and underlying or operating profit of $2.3 billion.
The seed vault that protects the worlds' seed crops, also protects European and South American varieties of aubergine, lettuce, barley and potatoes.
Early polls indicated broad support for the plan, but the most recent survey, published on May 10, showed the "yes" side slipping to 56 percent -- a drop of five points from late March.
Authorities declare quarantine against movement of chicken and ducks
Cholera cases in country could reach 300,000 within six months, WHO Yemen representative says
In recent years rangers have tried to clean up Khao Sam Roi Yot national park and this year were rewarded with a sea of pink flowers.
Over 17,200 suspected cases of cholera were reported in Yemen
Cholera has hit 13 of 18 Somalia’s provinces, in biggest outbreak in the country in 5 years, according to WHO
The fate of the superhighway remains on hold pending the final decision of the Abuja authorities, expected in the coming weeks.
The new policy would also help guarantee the labor and human rights of the six million small farmers and 30 million workers who harvest rubber in countries such as Indonesia, Thailand and Brazil.
Turkey makes strides in developing its medical tourism sector by implementing policies that facilitate foreign visitors
A prolonged drought descended on the region last year, shriveling two rivers that feed into Lake Atescatempa, and with it the flow of tourists to the area and the livelihood of residents.
The WHO says that pre-term birth complications in Indonesia are the leading cause of death among children under five.
The WHO said the outbreak affects an equatorial forest region in Bas-Uele province, bordering Central African Republic.