World Bulletin / News Desk
People using a common class of antidepressants may have slightly increased odds of suffering bleeding in the brain - though the risk is still very small, according to a Canadian study looking at more than 500,000 people.
The antidepressants are known as selective serotonin reuptake inhibitors (SSRIs) and include widely used drugs like fluoxetine (Prozac), sertraline (Zoloft), citalopram (Celexa) and paroxetine (Paxil.)
The SSRIs have been linked to a risk of stomach bleeding, but studies have come to conflicting findings on whether SSRI users have any higher risk of hemorrhagic strokes, which happen when there is bleeding in or around the brain.
For the study, which appeared in the journal Neurology, researchers pooled the findings from 16 past studies involving more than 500,000 people who were on SSRIs or not.
Overall, antidepressant users were about 40 to 50 percent more likely to suffer bleeding in or around the brain.
But while those numbers might sound big, the risks to any one person would be "extremely low," said lead researcher Daniel Hackam, an associate professor of medicine at Western University in London, Ontario, Canada.
Based on these figures, he said, there would be one brain hemorrhage for every 10,000 people using an SSRI over one year.
What's more, the findings do not prove that the antidepressants directly cause brain bleeds. It's possible, Hackham said, that SSRI users are "sicker" than non-users or have habits that put them at greater stroke risk.
The researchers tried to account for those factors in their calculations, but some of the studies they analyzed lacked key information, such as peoples's smoking and drinking habits, and whether they had diabetes.
"We can't infer cause and effect from this," Hackam said.
On the other hand, there are reasons to believe it's the medications themselves. For one, the hemorrhage risk seemed greatest in the first months after people started using an SSRI.
There's also a biological argument. SSRIs seem to make it harder for blood cells called platelets to clump together and form clots - and there can be a big drop in a person's platelet functions in the first weeks after starting an SSRI, he said.
Still, he stressed that people on the antidepressants should not be alarmed.
"I think that overall, these medications are quite safe," he added.
But people who are already at increased risk of a brain hemorrhage may need to be careful. That includes people who have had a brain bleed in the past, or are on medications that reduce blood clotting.
The plight of these urban areas show how dire the coming global freshwater shortage could get.
Coin-sized band analyzes blood glucose levels and releases insulin when needed
A WHO report has found that the use of lindane and DDT are linked to non-Hodgkin lymphoma
Pope Francis has said that the emissions trading is a ploy to allow wealthy emitters to continue their work
Russian sewerage dump is responsible for declining fish stock in the Baltic seas.
A new cancer drug will be tested as part of a joint effort by AstraZeneca and Lilly.
Smart technology and regulation will aid challenges in global power sector, helping to lower the carbon emitted globally.
A deal between the richest nations in the world has been seen as unlikely, as OECD seeks to phase out export credits.
Soon more than 1 billion consumers in developing nations will be able to buy their first air conditioner, increasing energy demand which will impact global warming
The European Union has given new authorization for 10 new types of genetically modified crops have been approved for a 10 year use for human consumption and animal feed.
Guinea's President Alpha Conde announced new emergency measures in Ebola fight on Saturday
'Meetings happened. Action didn’t,' says Medecins Sans Frontieres report.
WHO said that on many levels, the world is better prepared now than ever before for aflu pandemic
Myanmar health officals say an outbreak of H5N1 bird flu in Mandalay
Tokyo Electric said it has been aware since last spring that radiation levels in water running in one of the plant gutters rise when it rains
Safe drinking water is available at about one-third of the level it was before the conflict erupted nearly five years ago, and supplies are cut-off to punish civilians at times