Researchers launched a unique collaboration on Wednesday aimed at getting cancer drugs to the market more quickly in which three companies will cooperate with the U.S. government and non-profit groups to test five experimental breast cancer drugs.
The five-year, $26 million study called Investigation of Serial Studies to Predict your Therapeutic Response with Imaging and Molecular Analysis, or I-SPY2, will aim to use DNA to match the best drug to each patient and to more quickly toss out approaches that do not work or are too toxic.
"They'll get the latest and greatest in terms of targeted drugs," Dr. Anna Barker, deputy director of the National Cancer Institute, said in an interview.
"I think it's the future. Government couldn't have done it on their own and these companies couldn't have done it on their own."
Unusually, the companies agreed to share information on using genes to predict how well a patient will respond as part of the Biomarkers Consortium, which includes the U.S. Food and Drug Administration and the National Institutes of Health.
"I-SPY 2 will provide a path to personalized medicine," said Dr. Laura Esserman, a breast cancer surgeon at the University of California San Francisco who will help lead the clinical trials. "We intend that every drug will graduate with a companion marker."
The trial will match patients to one of five experimental drugs:
-- ABT-888 or veliparib, being developed by Abbott Laboratories. The pill is a PARP inhibitor, which blocks a cell repair enzyme used by cancer cells.
-- AMG 655 or conatumumab, a targeted drug being developed by Amgen. It boosts a protein called APO/TRAIL that causes cancer cells to self-destruct.
-- Amgen's AMG 386, an angiogenesis inhibitor that stops tumors from growing blood vessels to nourish themselves.
-- CP-751,871 or figitumumab, being developed by Pfizer Inc to target the insulin growth factor receptor or IGFR.
-- Pfizer's HKI-272 or neratinib, another targeted therapy called a Pan ErbB inhibitor that targets several related receptors used by cancer cells.
The group is negotiating with other companies to add their experimental drugs to the mix.
"It'll speed up the whole process," Barker said.
The drug company lobby group PhRMA estimates it can take as long as 15 years and cost more than $1.3 billion dollars to take a new drug from laboratory to pharmacy.
Patients at 20 cancer centers will be tested right after they get tiny samples of tissue taken in biopsies. Before they ever get surgery, they will be treated with one of the drugs to see if this helps prevent tumor spread.
Up to 12 different cancer drugs will be tested. Unusually, the group has FDA approval to drop and add drugs throughout the course of the trial without having to stop it to write a whole new protocol.
The weeklong campaign will target seven of South Sudan's ten states.
The latest cases bring the total number of confirmed cases in the kingdom to 272, of whom 81 have died.
In a survey conducted last year, most water analyzed was deemed to be "very poor" or "relatively poor" in standard and cannot be used for drinking purposes.
Poaching rhinos for their horns is a growing problem in South Africa and a lucrative business for organised criminal networks but it is unusual for thieves to target stock piles.
The 17 new cases, announced late on Monday on the Health Ministry website, bring the total number of Saudi infections to 261, of whom 81 have died
The amendments, now in their fourth draft, are expected to enshrine environmental protection as the overriding priority of the Chinese government
In 2008, the Zambian government banned smoking in public places, relying on state police to enforce the prohibition.
Saudi Arabia has reported 244 cases of MERS since the disease was identified in 2012, of which 79 have been fatal.
China is aiming to make energy production and consumption more ecological to fight smog, siad the Chinese Premier.
MERS has no vaccine or anti-viral treatment, but international and Saudi health authorities say the disease, which originated in camels, does not transmit easily between people and may simply die out
Blamed on the uncontrolled and overuse of farm chemicals, the level of contamination has raised a number of health concerns, with certain villages already showing higher rates of cancer than the national average.
The deputy minister called on South Sudanese farmers in states that have not been hit by famine to cultivate their farmlands to avoid exacerbating the crisis in the country.
Researchers determined that while the Guinean form of the Ebola virus (EBOV) showed a 97 percent similarity to the Zaire strain, the disease was not introduced from Central Africa.
Pakistan's army will join campaign to eradicate polio.
Instead of testing one drug at a time, a novel lung cancer study announced will allow British researchers to test up to 14 drugs from AstraZeneca and Pfizer at the same time within one trial
Australian Immigration Minister Scott Morrison's office said that medical officers at the centre had confirmed three cases of the potentially fatal tropical disease, which is transmitted by mosquitoes