Researchers launched a unique collaboration on Wednesday aimed at getting cancer drugs to the market more quickly in which three companies will cooperate with the U.S. government and non-profit groups to test five experimental breast cancer drugs.
The five-year, $26 million study called Investigation of Serial Studies to Predict your Therapeutic Response with Imaging and Molecular Analysis, or I-SPY2, will aim to use DNA to match the best drug to each patient and to more quickly toss out approaches that do not work or are too toxic.
"They'll get the latest and greatest in terms of targeted drugs," Dr. Anna Barker, deputy director of the National Cancer Institute, said in an interview.
"I think it's the future. Government couldn't have done it on their own and these companies couldn't have done it on their own."
Unusually, the companies agreed to share information on using genes to predict how well a patient will respond as part of the Biomarkers Consortium, which includes the U.S. Food and Drug Administration and the National Institutes of Health.
"I-SPY 2 will provide a path to personalized medicine," said Dr. Laura Esserman, a breast cancer surgeon at the University of California San Francisco who will help lead the clinical trials. "We intend that every drug will graduate with a companion marker."
The trial will match patients to one of five experimental drugs:
-- ABT-888 or veliparib, being developed by Abbott Laboratories. The pill is a PARP inhibitor, which blocks a cell repair enzyme used by cancer cells.
-- AMG 655 or conatumumab, a targeted drug being developed by Amgen. It boosts a protein called APO/TRAIL that causes cancer cells to self-destruct.
-- Amgen's AMG 386, an angiogenesis inhibitor that stops tumors from growing blood vessels to nourish themselves.
-- CP-751,871 or figitumumab, being developed by Pfizer Inc to target the insulin growth factor receptor or IGFR.
-- Pfizer's HKI-272 or neratinib, another targeted therapy called a Pan ErbB inhibitor that targets several related receptors used by cancer cells.
The group is negotiating with other companies to add their experimental drugs to the mix.
"It'll speed up the whole process," Barker said.
The drug company lobby group PhRMA estimates it can take as long as 15 years and cost more than $1.3 billion dollars to take a new drug from laboratory to pharmacy.
Patients at 20 cancer centers will be tested right after they get tiny samples of tissue taken in biopsies. Before they ever get surgery, they will be treated with one of the drugs to see if this helps prevent tumor spread.
Up to 12 different cancer drugs will be tested. Unusually, the group has FDA approval to drop and add drugs throughout the course of the trial without having to stop it to write a whole new protocol.
Residual sour gas was then burnt in flares at Kashagan's processing plants, polluting the environment, the ministry said in a statement.
Researchers from Britain and the United States found what they describe as the first hard evidence that malaria creeps to higher elevations during warmer years
The CPC's latest outlook brings the forecaster in line with other global meteorologists that have raised their outlook for El Nino's potential return this year.
The child is the second case, following an earlier instance in Mississippi, in which doctors may have brought HIV in a newborn into remission by administering antiretroviral drugs in the first hours of life.
"We will resolutely declare war against pollution as we declared war against poverty," PM Li told the almost 3,000 delegates to the country's largely rubber-stamp legislature in a wide-ranging address carried live on state television.
The research, which lends weight to campaigns for smoking to be banned in private cars and homes, found passive smoking leads to a thickening of children's artery walls, adding some 3.3 years to the age of blood vessels by adulthood.
Professor Jean-Michel Claverie, from the National Centre of Scientific Research (CNRS) at the University of Aix-Marseille in France, said "this is the first time we've seen a virus that's still infectious after this length of time."
The 76-year-old man died on Sunday, 75 days after the operation, the Georges Pompidou European Hospital in Paris said in a statement, adding that the cause of his death could not be known for sure at this stage.
Pacific islanders were eating fewer coconuts as a source of fat and many people in Southeast Asia were getting fewer calories from rice
The researchers had been able to clone the antibodies and would test if they were able to give immunity to a person without the virus
The condition of the baby with kidney disease returns to normal after doctors in the Turkish city of Konya decide against abortion to begin treatment in the womb
Australia's conservative government approved plans to dredge 3 million cubic metres of sand for the port expansion
Frequent nightmares were very common for one in ten children, especially between the ages of three and seven, but effects resulting from nightmares were much more severe in 12-year-olds.
The JAMA Psychiatry suggested that tihis was in connection to sperm mutations in men who become fathers relatively late in life, after comparing children of 24-year-old fathers and 45-year-old fathers.
Millions of people around the world go to bed hungry every night, and yet millions of tons of food end up in trash cans or spoiled on the way to market.
That change may result in per-serving calorie counts doubling for some foods such as ice cream.