"There is no justification for the closure of the Rafah crossing," Hamad al-Raqb, a spokesman for the protesters, said in a speech marking the beginning of a four-day sit-in.
"It is unbecoming of the historic relations between Egyptians and Palestinians," he insisted.
Leading Hamas figures and MPs attended the launch ceremony.
Egyptian authorities have tightened their control over the border with the Hamas-run Gaza Strip since last July's ouster of elected president Mohamed Morsi by the Egyptian army.
In recent weeks, Egypt has repeatedly closed the Rafah crossing, which – due to an ongoing, eight-year Israeli siege – represents Gaza's only window to the outside world.
The Egyptian army has also launched a campaign aimed at destroying the network of tunnels linking Gaza to Egypt's Sinai Peninsula, which in recent years had been used to bring vital commodities into the besieged coastal enclave, home to nearly 2 million Palestinians.
Hamas, an ideological offshoot of the Muslim Brotherhood, the group which propelled Morsi to power in the 2012 elections, has controlled the Gaza Strip, since 2007.
The United Nations said on Sunday, more than 90,000 people fleeing violence in Iraq's Anbar province
Twenty eight people were rescued in the incident, which happened in an area just off Libyan waters, 120 miles south of the southern Italian island of Lampedusa
Gaza Interior Ministry said Saturday, this has been the longest closure of the crossing since 2009
Ondo State's Health Commissioner said the number of deaths so far stands at 17. It has not yet been established that this is an infectious disease
"I am happy about that for Greece, But I do not think that this would solve the problems " German Finance Minister Wolfgang Schaeuble said on Saturday.
Abdullah Zekri, the the head of the French National Observatory against Islamophobia has said that anti-Muslim acts rose by 500 percent.
German Finance Minister said that while a gas deal with Russia will be good for Greece, it will not be sufficient to overcome their debt problems.
The Turkish Consulate General building in the Greek city of Thessaloniki has been damaged during a demonstration against high-security prisons Friday night.
Mauritanian news website Alakhbar posted an audio statement on Friday claiming the attack on peacekeepers was done on behalf of the armed group al-Mourabitoun.
Aden Haji Hussein was killed after he had taken his wife to hospital. The gunmen had blocked his path as he was returning to his car.
Iraqi armed forces have retaken the oil refinery that was seized on Friday by ISIL forces.
In December, Israel began withholding around $130 million per month of taxes it collects on behalf of the Palestinians after the Palestinian Authority announced it was joining the International Criminal Court (ICC).
The aim of the setting up of the graves was to draw attention to the Palestinian detainees languishing in Israeli jails.
Supreme Court president Lord Neuberger said judges must have “an understanding of different cultural and social habits,” as part of their duty to show fairness and impartiality in trials.
Libyan news website Ajwa Belad said the clashes in Fashloum started after an armed group attacked a checkpoint of an anti-drugs police force.