"There is no justification for the closure of the Rafah crossing," Hamad al-Raqb, a spokesman for the protesters, said in a speech marking the beginning of a four-day sit-in.
"It is unbecoming of the historic relations between Egyptians and Palestinians," he insisted.
Leading Hamas figures and MPs attended the launch ceremony.
Egyptian authorities have tightened their control over the border with the Hamas-run Gaza Strip since last July's ouster of elected president Mohamed Morsi by the Egyptian army.
In recent weeks, Egypt has repeatedly closed the Rafah crossing, which – due to an ongoing, eight-year Israeli siege – represents Gaza's only window to the outside world.
The Egyptian army has also launched a campaign aimed at destroying the network of tunnels linking Gaza to Egypt's Sinai Peninsula, which in recent years had been used to bring vital commodities into the besieged coastal enclave, home to nearly 2 million Palestinians.
Hamas, an ideological offshoot of the Muslim Brotherhood, the group which propelled Morsi to power in the 2012 elections, has controlled the Gaza Strip, since 2007.
Gnassingbe is currently on a three-day visit to Ghana for talks aimed at strengthening bilateral and trade relations.
A crucial week for Colombian peace talks amidst hostage liberations and rebel attacks.
George Galloway says that the wave of calls in European parliaments for recognizing the state of Palestine had its roots in 1982, when the Sabra and Shatila massacre took place during Israel's bloody invasion of Lebanon.
Amnesty International named the man as Osama al-Najjar, and said the "charade of a trial" showed what it called the authorities' intolerance of dissent.
Uganda's First Lady Janet Kataha Museveni said that despite "remarkable progress", there are still gaps.
Rami Abdulrahman, who runs the Britain-based Observatory, said 10 war planes struck at least 10 times in Raqqa, a stronghold of the ultra-hardline group ISIL
Ukrainian Foreign Ministry says Ukraine does not recognize alliance between Russia and self-proclaimed Republic of Abkhazia.
The court said that the CAA head cannot be sacked under Egypt's constitution.
Noor Hassan – a 21-year-old from Nablus – died and two others were injured when an Israeli bus rammed into them, an eyewitness said.
NBA superstars Kobe Bryant and Steve Nash: 'System kills young black men under the mask of law.'
The move came following remarks made by Nevo in which he reportedly said that the Jordanian parliament had only cared about marginal issues.
An air strike hit the last functioning commercial airport in Libya's capital Tripoli for a second day running on Tuesday, residents said, as a power struggle in the oil-rich nation intensified.
Around 2,500 women still detained or missing, the Syrian Network for Human Rights says.
Around 80 protesters arrested for assaulting police, illegal assembly, disobeying injunction, and obstructing police work.
Greek-Cypriot and Turkish Republic of NorthernCyprus should be allowed to develop their relationship, says British former Foreign Secretary
Nusra Front, which is fighting the regime of Syrian President Bashar al-Assad, killed and captured a number of Lebanese soldiers – including Shiite troops – in Lebanon's border town of Arsal