"There is no justification for the closure of the Rafah crossing," Hamad al-Raqb, a spokesman for the protesters, said in a speech marking the beginning of a four-day sit-in.
"It is unbecoming of the historic relations between Egyptians and Palestinians," he insisted.
Leading Hamas figures and MPs attended the launch ceremony.
Egyptian authorities have tightened their control over the border with the Hamas-run Gaza Strip since last July's ouster of elected president Mohamed Morsi by the Egyptian army.
In recent weeks, Egypt has repeatedly closed the Rafah crossing, which – due to an ongoing, eight-year Israeli siege – represents Gaza's only window to the outside world.
The Egyptian army has also launched a campaign aimed at destroying the network of tunnels linking Gaza to Egypt's Sinai Peninsula, which in recent years had been used to bring vital commodities into the besieged coastal enclave, home to nearly 2 million Palestinians.
Hamas, an ideological offshoot of the Muslim Brotherhood, the group which propelled Morsi to power in the 2012 elections, has controlled the Gaza Strip, since 2007.
The plan, a reported $4.1 trillion for 2018, is certain to undergo major changes on Capitol Hill, where lawmakers rarely approve a president's budget wish list in its original form.
While rolling out a new pricing system in the US, the San Francisco-based, on-demand ride service uncovered the error, which it said could cost tens of millions of dollars to correct.
UN Secretary-General Antonio Guterres made the proposal to the UN General Assembly to address a major shortfall in the $400 million needed to help Haiti recover from the epidemic.
Prosecutor General Adriatik Llalla says investigation will be carried out in accordance with Albanian law
Pro-government forces captured the district after overnight offensive
Tanzania, Uganda and Rwanda establish checking points at border posts
Peace talks between the Palestinians and Israel collapsed in 2014
Authorities in New York have stepped up security after a concert blast killed 19 people
Trump caused uproar when he suggested on the campaign trail he would check first if a NATO ally was up to date with its dues before he would consider coming to its aid.
Here is what we know so far about the terror attack, the deadliest in Britain since 2005.
African-American voters traditionally support the Democratic Party, while Republicans have an advantage with whites voters.
Donald Trump faces mounting calls for proceedings to be opened amid scandals
South Sudan has been at war since December 2013 when Kiir fell out with Machar, accusing him of plotting a coup.
"Just so you understand, I never mentioned the word or the name Israel," Trump said ahead of a bilateral session with Israeli Prime Minister Benjamin Netanyahu.
Despite winning 14 seats, the Socialist Party made a pre-election campaign promise not to enter into government with Rutte.
Trump's visit to Israel and the Palestinian territories is part of his first trip abroad as president, and follows an initial leg in Saudi Arabia, where he urged Islamic leaders to confront extremism.