Turkish scientists decode schizophrenia
Turkish scientists have discovered that excessive secretion of agmatine by brain caused schizophrenia which is a mental disorder with no treatment.
Professor Tayfun Uzbay, chairman of the Department of the Pharmacology of the Gulhane Military Medical Academy (GATA), said at a news conference on Thursday that he and his team conducted a series of experiments in the last five years on rats in the laboratory on effects of agmatine.
"While working on effects of alcohol, nicotine and heroin on human brain, we injected excessive amount of agmatine into rats and observed that they developed schizophrenia. This study led us to significant findings in diagnose and treatment of this mental disorder," he said.
He said that they also unveiled that three substance used in agriculture sector in the United States to kill fungus and parasites could be used in treatment of schizophrenia since they blocked agmatine synthesis.
"Any kit or method to detect agmatine in blood and cerebrospinal fluid (CSF) can help us to diagnose schizophrenia at an early age and assess its prognosis process," he added.
Results of their study was published in the European Neuropsychopharmacology and the Journal of Psychopharmacology.
Schizophrenia is characterized by abnormalities in the perception or expression of reality. Some of its symptoms include hallucinations, delusions, disorganized speech and thinking and significant social or occupational dysfunction.
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