The award was given by the American Association for Cancer Research (AACR).
"The Landon Foundation-AACR INNOVATOR Award for International Collaboration in Cancer Research is presented to a team of experts in genetics, thoracic oncology, geology and pathology working in the United States and Turkey," a statement from the AACR said.
Members of the award-winning research team include: lead researcher Michele Carbone, M.D., Ph.D., and Haining Yang, Ph.D., University of Hawaii; Nancy Cox, Ph.D., and Ian Steele, Ph.D., University of Chicago; Harvey Pass, M.D., NYU School of Medicine and Clinical Cancer Center; Joseph Testa, Ph.D., Fox Chase Cancer Center; Y. İzzetin Barış, M.D., University of Hacettepe in Ankara, Turkey; A. Ümran Doğan, Ph.D., University of Iowa; and Salih Emri, M.D., and Murat Tuncer, M.D., Hacettepe University School of Medicine in Ankara, Turkey.
"'International collaborations are essential to addressing the cancer problem on a global scale. To ensure continued progress in conquering cancer, researchers must be willing to share resources and technologies, lend expertise and communicate new concepts, perspectives and methodologies to the worldwide cancer community,' said Doctor Margaret Foti, the AACR's chief executive officer," according to the statement.
The statement went on to say: "Carbone and his team of international collaborators have discovered a unique mesothelioma epidemic in three Turkish villages in Cappadocia and have demonstrated that it is caused by a genetic predisposition to mineral fiber carcinogenesis, a gene-environment interaction. Mesothelioma is a form of cancer where malignant cells develop in the mesothelium, a protective lining that covers most of the body's internal organs. Carbone and colleagues have identified exposure to erionite as the likely cause of the epidemic and have reduced exposure to that mineral fiber throughout the villages. They will apply the AACR INNOVATOR grant to their study of linkage analysis to identify the predisposing gene or genes for mesothelioma among this cultural group and map the genetic risk factors by genetic linkage studies. Findings from this research have implications far beyond the villages in Turkey as they can be applied to other geographic areas and communities worldwide with the goal of preventing this deadly form of cancer or finding new life-saving treatments, said the ACCR statement."
Meanwhile, an article written by Carbone's team and published in the US-based Nature Reviews Cancer magazine's February 2007 edition, stated that the unprecedented mesothelioma epidemic causes 50 percent of all deaths in three small villages in Cappadocia.
The article said: "Initially linked solely to the exposure to a fibrous mineral, erionite, recent studies by scientists from Turkey and the United States have shown that erionite causes mesothelioma mostly in families that are genetically predisposed to mineral fibre carcinogenesis. This manuscript reports, through the eyes of one of the researchers, the resulting scientific advances that have come from these studies and the social improvements that were brought about by both the scientists and members of the Turkish Government."
Last Mod: 05 Mayıs 2008, 15:50