Afghan and NATO-led forces killed at least 30 suspected fighters in an air and ground assault in eastern Afghanistan on Saturday, NATO forces said in a statement.
The NATO-led International Security Assistance Force (ISAF) said more than 250 Afghan security forces and coalition troops attacked in Laghman province, southeast of the capital Kabul.
There were no immediate reports of coalition or civilian casualties in the assault, which ISAF said was continuing.
A report by the Afghanistan Rights Monitor said nearly 1,100 civilians were killed in the first half of 2010 in NATO attacks.
WikiLeaks unveiled reports of U.S. army that shows thousands of unreported civilian deaths in the near nine-year-old war.
Civilian deaths caused by foreign forces are a major source of friction between Afghan President Hamid Karzai and his Western backers, whose 150,000 troops are engaged in an invasion caused bloodshed accross South Asian country.