An intelligence official confirmed the drone attack to Anadolu Agency.
He said the unmanned plane targeted a compound near Miramshah, the capital of North Waziristan, in the early hours of Sunday.
"Taliban and Al-Qaeda militants were the target of strike," he said.
"However, it is not possible to tell about the nationality of deceased," added the official, wishing not to be named.
Addressing the UN General Assembly in New York on Friday, Sharif dismissed the drone attacks as a violation of Pakistan's sovereignty.
"The attacks conducted by US-led NATO forces on Pakistani soil using unmanned spy planes are counter-productive to the anti-extremism efforts," he insisted.
"It results in casualties of innocent civilians and is detrimental to our resolve and efforts to eliminate extremism and terrorism from Pakistan."
More than 3,000 people, including women and children, have been killed in drone attacks since 2004.
Some 116 Al-Qaeda and Taliban fighters, according to the Washington-based think tank New American Foundation, have also been killed in drone attacks.
The US describes the drone attacks as the most precise and useful weapon against Al-Qaeda and Taliban holding up in Waziristan.
However, human rights organizations and independent think tanks, like New American Foundation and Bureau of Investigative Journalism, say that 70 percent of the people killed in drones were civilians.