"The so-called American framework is not binding for us," Haniya said during a reception of former female prisoners in the Gaza City.
"This framework to resolve the Palestinian issue is unfair and imposes the Zionist violation of the Palestinian land."
The West Bank-based Palestinian Authority (PA), which has been engaged in peace talks with Israel since July, also rejects many articles of Kerry's plan, saying it adopts Israel's vision and neglected the Palestinian demands.
The framework is meant to serve as a basis to extend the US-brokered negotiations when their nine-month tenure ends in April.
The Palestinians, who see the talks as unproductive, oppose any extension of the two-state negotiations.
Among the PA's reservations on Kerry's plan is that it does not include massive evacuation of Jewish settlements in the West Bank and allows Israel to retain military presence on the vital Jordan Valley area, which the Palestinians demand as part of their future state.
Haniyeh renewed Hamas' opposition of peace negotiations with Israel, insisting that armed resistance was "the only strategy to liberate the land."
Hamas would not agree to give up "any inch of the land of Palestine," he said.